Publications

Below you find a list of the publications of our CRC 969, sorted by year and in alphabetical order. Clicking on the links will guide you to either the PubMed database (“short”) or to the full length article on the respective journal´s homepage.

2024

• Bongiovanni, T.R., Latario, C.J., Le Cras, Y., Trus, E., Robitaille, S., Swartz, K., Schmidtke, D., Vincent, M., Kosta, A., Orth, J., Stengel, F., Pellarin, R., Rocha, E.P.C., Ross, B.D., and Durand, E. (2024) Assembly of a unique membrane complex in type VI secretion systems of Bacteroidota. Nat. Commun. 15, 429 short | full
• Kammer, K.-M., Eisgruber, T., Heid, P., Pellarin, R., and Stengel, F. (2024) Kinetic principles of chemical cross-link formation for protein-protein interactions. Proc. Natl. Acad. Sci. USA 121, e2402040121 short | full
• Kläge, D., Müller, E., and Hartig, J.S. (2024) A comparative survey of the influence of small self-cleaving ribozymes on gene expression in human cell culture. RNA Biol. 21, 1-11  short | full
• Kufleitner, M., Haiber, L. M., Li, S., Surendran, H., Mayer, T.U., Zumbusch, A., and Wittmann, V. (2024) Next-generation metabolic glycosylation reporters enable detection of protein O-GlcNAcylation in living cells without S-glyco modification. Angew. Chem. Int. Ed. Engl. 63, e202320247 short | full
• Maguire, S.,Scheibe, C., Eisgruber, T., Mosesso, N., Isono, E., and Hauser, K. (2023) Membrane-specific and calcium-dependent binding of the Arabidopsis C2 domain protein CaLB revealed by ATR-FTIR spectroscopy. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 15, 123629, short | full
• Mosesso, N., Savant Lerner, N., Bläske, T.,  Groh, F., Maguire, S., Niedermeier, M.L., Landwehr, E. , Vogel, K., Meergans, K., Nagel, M.-K., Drescher, M., Stengel, F., Hauser, K., and Isono, E. (2024) Arabidopsis CaLB1 undergoes phase separation with the ESCRT protein ALIX and modulates autophagosome maturation. Nat. Commun. 15, 5188 short | full
• Saumer, P., Scheffner, M., Marx, A., and Stengel, F. (2024) Interactome of intact chromatosome variants with site-specifically ubiquitylated and acetylated linker histone H1.2. Nucleic Acids Res. 52, 101-113 short | full
• Saxena, K., Inholz, K., Basler, M., and Aichem, A. (2024) FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretion. Life Sci. Alliance 7, 202402786 short | full
• Vogel, K., and Isono, E. (2024) Erasing marks: Functions of plant deubiquitylating enzymes in modulating the ubiquitin code. Plant Cell, epub ahead of print short | full

2023

• Brockmann, F., Catone, N., Wünsch, C., Offensperger, F., Scheffner, M., Schmidtke, G., and Aichem, A. (2023) FAT10 and NUB1L cooperate to activate the 26S proteasome. Life Sci. Alliance 6, e202201463 short | full
• Dröden, J., and Drescher, M. (2023) Rapid scan electron paramagnetic resonance spectroscopy is a suitable tool to study intermolecular interactions of intrinsically disordered protein. Biology 12, 79 short | full
• Gamerdinger, M., Jia, M., Schloemer, R., Rabl, L., Jaskolowski, M., Khakzar, K.M., Ulusoy, Z., Wallisch, A., Jomaa, A., Hunaeus, G., Scaiola, A., Diederichs, K., Ban, N., and Deuerling, E. (2023) NAC controls cotranslational N-terminal methionine excision in eukaryotes. Science 380, 1238–1243 short | full
• Gamerdinger, M., and Deuerling, E. (2023) Cotranslational sorting and processing of newly synthesized proteins in eukaryotes. Trends Biochem. Sci., epub ahead of print short | full
• Hunkler, S., Diederichs, K., Kukharenko, O., and Peter, C. (2023) Fast conformational clustering of extensive molecular dynamics simulation data. J. Chem. Phys. 158, 144109 short | full
• Hunkler, S., Buhl, T., Kukharenko, O., and Peter, C. (2023) Generating a conformational landscape of ubiquitin chains at atomistic resolution by back-mapping based sampling. Front. Chem. 10, 1087963 short | full
• Immler, F., Schneider, T., and Kovermann, M. (2023) Targeted preparation and NMR spectroscopic characterization of Lys11-linked ubiquitin trimers. ChemBioChem, Nov 20:e202300670 short | full
• Jaskolowski, M., Jomaa, A., Gamerdinger, M., Shrestha, S., Leibundgut, M., Deuerling, E., and  Ban, N. (2023) Molecular basis of the TRAP complex function in ER protein biogenesis. Nat. Struct. Mol. Biol., 30, 770-777 short | full
• Kranaster, P., Blum, J., Dold, J.E.G.A., Wittmann, V., and Leist, M. (2023) Use of metabolic glycoengineering and pharmacological inhibitors to assess lipid and protein sialylation on cells. J. Neurochem., 164, 481-498 short | full
• Kufleitner, M., Haiber, L.M., and Wittmann, V. (2023) Metabolic glycoengineering – exploring glycosylation with bioorthogonal chemistry. Chem. Soc. Rev. 52, 510-535 short | full
• Mueller, S., Bialas, J., Ryu, S., Catone, N., and Aichem, A. (2023) The ubiquitin-like modifier FAT10 covalently modifies HUWE1 and strengthens the interaction of AMBRA1 and HUWE1. PLoS One, 18, e0290002 short | full
• Oliveri, F., Keller, S.J., Goebel, H., Alvarez Salinas, G.O., and Basler, M. (2023) The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro but not in cellulo. Life Sci. Alliance, 6, e202201760 short | full
• Saldanha, O., Schiller, L., and Hauser, K. (2023) Calcium-induced compaction and clustering of vesicles tracked with molecular resolution. Biophys. J. epub ahead of print short | full
• Savchenko, V., Szamosvári, D., Bao, Y., Pignitter, M., and Böttcher, T. (2023) Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response. Commun. Chem., 6, 138 short | full
• Sawade, K., Marx, A., Peter, C., and Kukharenko, O. (2023) Combining molecular dynamics simulations and scoring method to computationally model ubiquitylated linker histones in chromatosomes. PLoS Comput. Biol., 19, e1010531 short | full
• Saxena, K., Roverato, N.D., Reithmann, M., Mah, M.M., Schregle, R., Schmidtke, G., Silbern, I., Urlaub, H., and Aichem, A. (2023) FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon response. Life Sci. Alliance, 7, e202101282 short | full
• Schneider, T., Sawade, K., Berner, F., Peter, C., and Kovermann, M. (2023) Specifying conformational heterogeneity of multi-domain proteins at atomic resolution. Structure, epub ahead of print short | full
• Schnell, L., Zubrod, A., Catone, N., Bialas, J., and Aichem, A. (2023) Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions. Life Sci. Alliance, 6, e202301985 short | full
• Silkenath, B., Kläge, D., Altwein, H., Schmidhäuser, N., Mayer, G., Hartig, J.S., and Wittmann, V. (2023) Phosphonate and thiasugar analogues of glucosamine-6-phosphate: Activation of the glmS riboswitch and antibiotic activity. ACS Chem. Biol., 18, 2323-2334 short | full
• Stritt, P., Jawurek, M., and Hauser, K. (2023) Mid-IR quantum cascade laser spectroscopy to resolve lipid dynamics during the photocycle of bacteriorhodopsin. J. Chem. Phys. 158, 154202 short | full
• Ückert, A.-K., Rütschlin, S., Gutbier, S., Wörz, N.C., Miah, M.R., Martins, A.C., Hauer, I., Holzer, A.-K., Meyburg, B., Mix, A.-K., Hauck, C.R., Aschner, M., Böttcher, T, and Leist, M. (2023) Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration. Environ. Int. 180, 108229 short | full

2022

• Bogomolovas, J., Gravenhorst, P., and Mayans, O. (2022) Production and analysis of titin kinase: Exploiting active/inactive kinase homologs in pseudokinase validation. Methods Enzymol. 667, 147-181 short | full
• Del Rio Oliva, M., Kirk, C.J., Groettrup, M., and Basler, M. (2022) Effective therapy of polymyositis in mice via selective inhibition of the immunoproteasome. Eur. J. Immunol. 52, 1510-1522 short | full
• Del Rio Oliva, M., and Basler, M. (2022) Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage. Cell Death Dis. 13, 1015 short | full
• Del Rio Oliva, M., Mellet, M., and Basler, M. (2022) Immunoproteasome inhibition attenuates experimental psoriasis. Front. Immunol. 13, 1075615 short | full
• Grimm, T.M., Herbinger, M., Krüger, L., Müller, S., Mayer, T.U., and Hauck, C.R. (2022) Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion. Cell Chem. Biol. epub ahead of print short | full
• Heim, A., Niedermeier, M.L., Stengel, F., and Mayer, T.U. (2022) The translation regulator Zar1l controls timing of meiosis in Xenopus oocytes. Development 149, dev200900 short | full
• Jomaa, A., Gamerdinger, M., Hsieh, H.-H., Wallisch, A., Chandrasekaran, V., Ulusoy, Z., Scaiola, A., Hegde, R.S., Shan, S.-O., Ban, N., and Deuerling, E. (2022) Mechanism of signal sequence handover from NAC to SRP on ribosomes during ER-protein targeting. Science 375, 839-844 short | full
• Julier, A., Radtke, V., Marx, A., and Scheffner, M. (2022) Generation and characterization of site-specifically mono-ubiquitylated p53. ChemBiochem 23, e20210065 short | full
• Kienle, S., Schneider, T., Stuber, K., Globisch, C., Jansen, J., Stengel, F., Peter, C., Marx, A., Kovermann, M., and Scheffner, M. (2022) Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function. Nat. Commun. 3, 5435 short | full
• Nellinger, S., Rapp, M.A., Southan, A., Wittmann, V., Kluger, P.J. (2022) An advanced ‘clickECM’ that can be modified by the Inverse-Electron-Demand Diels-Alder reaction. ChemBioChem, 22, 1-10 short | full
• Oliveri, F., Basler, M., Nageswara Rao, T., Fehling, H.J., and Groettrup, M. (2022) Immunoproteasome inhibition reduces the T Helper 2 response in mouse models of allergic airway inflammation. Front. Immunol. 13, 870720 short | full
• Sailer, C., Jansen, J., Sekulski, K., Cruz, V.E., Erzberger, J.P., and Stengel, F. (2022) A comprehensive landscape of 60S ribosome biogenesis factors. Cell Rep. 38, 110353 short | full
• Sawade, K., and Peter, C. (2022) Multiscale simulations of protein and membrane systems. Curr. Opin. Struct. Biol. 72, 203-208 short | full
• Schmid, P., Peñalver, L. and Böttcher, T. (2022) A ligand selection strategy to customize small molecule probes for activity-based protein profiling (LS-ABPP). Methods Enzymol. 664, 23-58 short | full
• Siu, H.-W., and Hauser, K. (2022) Observation of oligomeric states indicates a high structural flexibility required for the onset of Polyglutamine fibrillization. J. Phys. Chem. Lett. 13, epub ahead of print full
• Siu, H.-W., Stritt, P., Zhao, H., and Hauser, K. (2022) PolyQ aggregation studied by model peptides with intrinsic tryptophan fluorophores. Biophys. Chem. epub ahead of print full

2021

• Basler, M., and Groettrup, M. (2021) On the role of the immunoproteasome in protein homeostasis. Cells, 10, 3216 short | full
• Basler, M., Christ, M., Goebel, H., and Groettrup, M. (2021) Immunoproteasome upregulation is not required to control protein homeostasis during viral infection. J. Immunol., epub ahead of print short | full
• Bhat, A., Li, S., Hammler, D., Winterhalder, M. J., Marx, A., and Zumbusch, A. (2021) Live cell imaging of enzymatic turnover of an adenosine 5’-tetraphosphate analog. Int. J. Mol. Sci. 22, 8616 short | full
• Bogomolovas, J., Fleming, J.R., Franke, B., Manso, B., Simon, B., Gasch, A., Markovic, M., Brunner, T., Knöll, R., Chen, J., Labeit, S., Scheffner, M., Peter, C., and Mayans, O. (2021) Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere. EMBO Rep. e48018 short | full
• Braun, T.S., Stehle, J., Kacprzak, S., Carl, P., Höfer, P., Subramaniam, V., and Drescher, M. (2021)  Intracellular protein-lipid interactions studied by rapid-scan Electron Paramagnetic Resonance Spectroscopy. J. Phys. Chem. Lett., 12, 2471-2475 short | full
• Dold, J.E.G.A., and Wittmann, V. (2021) Metabolic glycoengineering with azide- and alkene-modified hexosamines: Quantification of sialic acid levels. ChemBioChem, 22, 1243-1251 short | full
• Finke, M., Brecht, D., Stifel, J., Gense, K., Gamerdinger, M., and Hartig, J.S. (2021) Efficient splicing-based RNA regulators for tetracycline-inducible gene expression in human cell culture and C. elegans. Nucleic Acids Res. 49, e71 short | full
• Fries, S., Braun, T.S., Globisch, C., Peter, C., Drescher, M., and Deuerling, E. (2021) Deciphering molecular details of the RAC–ribosome interaction by EPR spectroscopy. Sci. Rep., 11, 8681 short | full
• Fürsch, J., Voormann, C., Kammer, K.M., and Stengel, F. (2021) Structural probing of Hsp26 activation and client binding by quantitative cross-linking mass spectrometry. Anal. Chem. epub ahead of print short | full
• Haiber, M.L., Kufleitner, M., and Wittmann, V. (2021) Application of the inverse-electron-demand Diels-Alder reaction for metabolic glycoengineering. Front. Chem. 9, 654932 short | full
• Held, T., Basler, M., Knobeloch, K.-P., and Groettrup, M. (2021) Evidence for an involvement of the ubiquitin‐like modifier ISG15 in MHC class I antigen presentation. Eur. J. Immunol., 51, 138-150 short | full
• Hoefer, F., and Groettrup, M. (2021) Silencing of the proteasome and oxidative stress impair endoplasmic reticulum targeting and signal cleavage of a prostate carcinoma antigen. Biochem. Biophys. Res. Commun. 554, 56-62 short | full
• Höllmüller, E., Greiner, K., Kienle, S.M., Scheffner, M., Marx, A., and Stengel, F. (2021) Interactome of site-specifically acetylated linker histone H1. J. Proteome Res. 20, 4443-4451 short | full
• Höllmüller, E., Geigges, S., Niedermeier, M.L., Kammer, K.M., Kienle, S.M., Rösner, D., Scheffner, M., Marx, A., and Stengel, F. (2021) Site-specific ubiquitylation acts as a regulator of linker histone H1. Nat. Commun. 12, 3497 short | full
• Isono, E. (2021) ESCRT is a great sealer: Non-endosomal function of the ESCRT machinery in membrane repair and autophagy. Plant Cell Physiol. epub ahead of print short | full
• Nikolay, N., Hilal, T., Schmidt, S., Qin, B., Schwefel, D., Vieira-Vieira, C.H., Mielke, T., Bürger, J., Loerke, J., Amikura, K., Flügel, T., Ueda, T., Selbach, M., Deuerling, E., and Spahn, C.M.T. (2021) Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol. Cell, 81, 1200-1215 short | full
• Peñalver, L., Schmid, P., Szamosvári, D., Schildknecht, S., Globisch, C., Sawade, K., Peter, C., and Böttcher, T. (2021) A ligand selection strategy identifies chemical probes targeting the proteases of SARS-CoV-2. Angew. Chem. Int. Ed. 20. 60, 6799-6806 short | full
• Prothiwa, M., Filz, V., Oehler, S., and Böttcher, T. (2021) Inhibiting quinolone biosynthesis of Burkholderia. Chem. Sci., 12, 6908-6912 full
• Roverato, N.D., Sailer, C., Catone, N., Aichem, A., Stengel, F., and Groettrup, M. (2021) Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy. Cell Rep., 34, 108857 short | full
• Scheibe, C., Karreman, C., Schildknecht, S., Leist, M., Hauser, K. (2021) Synuclein family members prevent membrane damage by counteracting α-synuclein aggregation. Biomolecules, 11, 1067 full
• Siu, H.-W., Heck, B., Kovermann, M., and Hauser, K. (2021) Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation. Chem. Sci.12, 412-426 short | full
• Stuber, K., Schneider, T., Werner, J., Kovermann, M., Marx, A., and Scheffner, M. (2021) Structural and functional consequences of NEDD8 phosphorylation. Nat. Commun. 12, 5939 short | full

2020

• Aichem, A., and Groettrup, M. (2020) The ubiquitin-like modifier FAT10 – much more than a proteasome-targeting signal. J. Cell Sci., 133, jcs246041 short | full
• Berg, A., Franke, L., Scheffner, M., and Peter, C. (2020) Machine learning driven analysis of large scale simulations reveals conformational characteristics of Ubiquitin chains. J. Chem. Theory Comput. 16, 3205-3220 short | full
• Böhm, A.N., Bialas, J., Catone, N., Sacristán-Reviriego, A., van der Spuy, J., Groettrup, M., and Aichem, A. (2020) The ubiquitin-like modifier FAT10 inhibits retinal PDE6 activity and mediates its proteasomal degradation. J. Biol. Chem., 14. Aug. 2020, epub ahead of print short | full
• Boycheva Woltering, S., and Isono, E. (2020) Knowing when to self-eat – fine-tuning autophagy through ATG8 iso-forms in plants. Front. Plant Sci., 11, 579875 short | full
• Braun, T.S., Widder, P., Osswald, U., Groß, L., Williams, L., Schmidt, M., Helmle, I., Summerer, D., and Drescher, M. (2020) Isoindoline-based nitroxides as bioresistant spin labels for protein labeling through cysteines and alkyne-bearing noncanonical amino acids. ChemBioChem, 21, 958-962 short | full
• Ebner, F.A., Sailer, C., Eichbichler, D., Jansen, J., Sladewska-Marquardt, A., Stengel, F., and Scheffner, M. (2020) A ubiquitin variant-based affinity approach selectively identifies substrates of the ubiquitin ligase E6AP in complex with HPV-11 E6 or HPV-16 E6. J. Biol. Chem. 27. Aug. 2020, epub ahead of print short | full
• Fürsch, J., Kammer, K.M., Kreft, S.G., Beck, M., and Stengel, F. (2020) Proteome-wide structural probing of low-abundant protein interactions by cross-linking mass spectrometry. Anal. Chem., 18. Feb. 2020, epub ahead of print short | full
• Grimm, T.M., Dierdorf, N.I., Betz, K., Paone, C., and Hauck, C. R. (2020) PPM1F controls integrin activity via a conserved phospho-switch. J. Cell Biol. 219, e202001057 short | full
• Hammler, D., Stuber, K., Offensperger, F., Scheffner, M., Zumbusch, A., and Marx, A. (2020) Fluorescently labelled ATP analogues for direct monitoring of Ubiquitin activation. Chemistry, 26, 6279-6284 short | full
• Isono, E. (2020) TOL keepers for Ubiquitin-mediated trafficking routes in plant cells. Mol. Plant 13, 685-687 short | full
• Kranaster, P., Karreman, C., Dold, J.E.G.A., Krebs, A., Funke, M., Holzer, A.K., Klima, A.S., Nyffeler, J., Helfrich, S., Wittmann, V., and Leist, M. (2020) Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity. Arch. Toxicol. 94, 449-467 short | full
• Krüger, A., Bürkle, A., Hauser, K, and Mangerich, A. (2020) Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy. Nat. Commun. 11, 2174 short | full
• Lutz, J., Höllmüller, E., Scheffner, M., Marx, A., and Stengel, F. (2020) The length of a ubiquitin chain is a determinant for selective recognition by ubiquitin-binding proteins. Angew. Chem. Int. Ed. 17. April, epub ahead of print short | full
• Mah, M.M., Roverato, N., and Groettrup, M. (2020) Regulation of Interferon induction by the Ubiquitin-like modifier FAT10. Biomolecules, 10, 951 short | full
• Pawar, A., Basler, M., Goebel, H., Alvarez Salinas, G. O., Groettrup, M., and Böttcher, T. (2020) Competitive metabolite profiling of natural products reveals subunit specific inhibitors of the 20S proteasome. ACS Cent. Sci., 21. Jan. 2020, epub ahead of print full
• Prothiwa, M., and Böttcher, T. (2020) Competitive profiling for enzyme inhibitors using chemical probes. Meth. Enzymol., 633, 49-69 short | full
• Scheerer, D., Chi, H., McElheny, D., Keiderling, T.A., and Hauser, K. (2020) Enhanced sensitivity to local dynamics in peptides by use of temperature-jump IR spectroscopy and isotope labeling. Chemistry, 26, 3524-3534 short | full
• Schregle, R., Müller, S., Legler, D.F., Rossy, J., Krüger, W.A., and Groettrup, M. (2020) FAT10 localises in dendritic cell aggresome-like induced structures and contributes to their disassembly. J. Cell Sci., 133, jcs240085 short | full
• Shanidze, N., Lenkeit, F., Hartig, J.S., and Funck, D. (2020) A theophylline-responsive riboswitch regulates expression of nuclear-encoded genes in Arabidopsis. Plant Physiol. 182, 123-135 short | full
• Weickert, S., Wawrzyniuk, M., John, L.H., Rüdiger, S.D.G., and Drescher, M. (2020) The mechanism of Hsp90-induced oligomerizaton of Tau. Sci. Adv., 6, eaax6999 short | full
• Widder, P., Schuck, J., Summerer, D., and Drescher, M. (2020) Combining site-directed spin labeling in vivo and in-cell EPR distance determination. Phys. Chem. Chem. Phys. 19. Feb. 2020, epub ahead of print short | full

2019

• Adams, M., Fleming, J.R., Riehle, E., Zhou, T., Zacharchenko, T., Markovic, M., and Mayans, O. (2019) Scalable, non-denaturing purification of phosphoproteins using Ga³⁺-IMAC: N2A and M1M2 Titin components as study case. Protein J. 38, 181-189 short | full
• Aichem, A., Sailer, C., Ryu, S., Catone, N., Stankovic-Valentin, N., Schmidtke, G., Melchior, F., Stengel, F., and Groettrup, M. (2019) The ubiquitin-like modifier FAT10 interferes with SUMO activation. Nat. Commun. 1. Oct. 2019, epub ahead of print short | full
• Aichem, A., Böhm, A.N., Catone, N., Schmidtke, G., and Groettrup, M. (2019) Analysis of modification and proteolytic targeting by the ubiquitin-like modifier FAT10. Meth. Enzymol. 618, 229-256 short | full
• Baade, T., Paone, C., Baldrich, A., and Hauck, C.R. (2019) Clustering of integrin β cytoplasmic domains triggers nascent adhesion formation and reveals a protozoan origin of the integrin-talin interactions. Sci. Rep. 9, 5728 full
• Basler, M., Claus, M., Klawitter, M., Goebel, H., and Groettrup, M. (2019) Immunoproteasome inhibition selectively kills human CD14⁺ monocytes and as a result dampens IL-23 secretion. J. Immunol. 4. Sept. 2019, epub ahead of print short | full
• Berg, A., and Peter, C. (2019) Simulating and analysing configurational landscapes of protein-protein contact formation. Interface Focus 9, 20180062 full
• Bialas, J., Böhm, A.N., Catone, N., Aichem, A., and Groettrup, M. (2019) The ubiquitin-like modifier FAT10 stimulates the activity of the deubiquitylating enzyme OTUB1. J. Biol. Chem. 294, 4315-4330 short | full
• Braun, T., Drescher, M., and Summerer, D. (2019) Expanding the genetic code for site-directed spin labeling. Int. J. Mol. Sci. 20, 373 short | full
• Cattani, J., Braun, T., and Drescher, M. (2019) Probing alpha-Synuclein conformations by Electron Paramagnetic Resonance (EPR) spectroscopy. Meth. Mol. Biol. 1948, 247-260 short | full
• Deuerling, E., Gamerdinger, M., and Kreft, S.G. (2019) Chaperone interactions at the ribosome. Cold Spring Harb. Perspect. Biol. epub ahead of print; doi: 10.1101/cshperspect.a033977 short | full
• Doll, F., Steimbach, R.R., and Zumbusch, A. (2019) Direct imaging of protein-specific methylation in mammalian cells. ChemBioChem 20, 1315-1325 short | full
• Fallah, M.A., and Hauser, K. (2019) Immobilization approaches can affect proteindynamics: a surface-enhanced infraredspectroscopic study on lipid–protein interactions. Biomater. Sci. 7, 3204-3212 short | full
• Gamerdinger, M., Kobayashi, K., Wallisch, A., Kreft, S.G., Sailer, C., Schlömer, R., Sachs, N., Jomaa, A., Stengel, F., Ban, N., and Deuerling, E. (2019) Early scanning of nascent polypeptides inside the ribosomal tunnel by NAC. Mol. Cell, epub ahead of print short
• Gerding, H.R.,  Karreman, C., Daiber, A., Delp, J., Hammler, D., Mex, M., Schildknecht, S., and Leist, M. (2019) Reductive modification of genetically encoded 3-nitrotyrosine sites in alpha synuclein expressed in E. coli. Redox Biol. epub ahead of print doi:10.1016/j.redox.2019.101251, full
• Hassenrück, J., and Wittmann, V. (2019) Cyclopropene derivatives of aminosugars for metabolic glycoengineering. Beilstein J. Org. Chem. 15, 584-601 short | full
• Hunkler, S., Lemke, T., Peter, C., and Kukharenko, O. (2019) Back-mapping based sampling: Coarse grained free energy landscapes as a guideline for atomistic exploration. J. Chem. Phys. 151, 154102 short | full
• Kargas, V., Castro-Hartmann, P., Escudero-Urquijo, N., Dent, K., Hilcenko, C., Sailer, C., Zisser, G., Carvalho, M., Pellegrino, S., Wawiórka, L., Freund, S., Wagstaff, J., Andreeva, A., Faille, A., Chen, E., Stengel, F., Bergler, H., and Warren, A.J. (2019) Mechanism of completion of peptidyltransferase centre assembly in eukaryotes. eLife, 8:e44904
• Köhn, B., and Kovermann, M. (2019) Macromolecular crowding tunes protein stability by manipulating solvent accessibility. ChemBioChem 20, 759-763 short | full
• Krüger, A., Stier, A., Fischbach, A., Bürkle, A., Hauser, K., and Mangerich, A. (2019) Interactions of p53 with poly(ADP-ribose) and DNA induce distinct changes in protein structure as revealed by ATR-FTIR spectroscopy. Nucleic Acids Res. 47, 4843-4858 short | full
• Kugele, A., Silkenath, B., Langer, J., Wittmann, V., and Drescher, M. (2019) Protein spin labeling with a photocaged nitroxide using Diels-Alder chemistry. ChemBioChem epub ahead of print short | full
• Kugele, A., Braun, T., Widder, P., Williams, L., Schmidt, M.J., Summerer, D., and Drescher, M. (2019) Site-directed spin labelling of proteins by Suzuki-Miyaura coupling via a genetically encoded aryliodide amino acid. Chem. Commun. 55, 1923-1926 short | full
• Lemke, T., Berg, A, Jain, A., and Peter, C. (2019) EncoderMap(II): Visualizing important molecular motions with improved generation of protein conformations. J. Chem. Inf. Model 59, 4550-4560 short | full
• Li, J., Koerner, J., Basler, M., Brunner, T., Kirk, C.J., and Groettrup, M. (2019) Immunoproteasome inhibition induces plasma cell apoptosis and preserves kidney allografts by activating the unfolded protein response and suppressing plasma cell survival factors. Kidney Int. 95, 611-623 short | full
• Marx, A. (2019) Science at the chemistry biology interface, some personal thoughts. Isr. J. Chem. 59, 1-8 full
• Mosesso, N., Nagel, M.-K., and Isono, E. (2019) Ubiquitin recognition in endocytic trafficking – with or without ESCRT-0. J. Cell Sci., 132,  jcs232868 short | full
• Mosesso, N., Bläske, T., Nagel, M.-K., Laumann, M., and Isono, E. (2019) Preparation of clathrin-coated vesicles from Arabidopsis thaliana seedlings. Front. Plant. Sci. 9, 1972 short | full
• Sack, M., Stifel, J., Kreft, S.G., Deuerling, E., and Hartig, J.S. (2019) Neomycin-dependent Hammerhead ribozymes for the direct control of gene expression in Saccharomyces cerevisiae. Methods, 161, 35-40 short | full
• Schart, V.F., Hassenrück, J., Späte, A.-K., Dold, J.E.G.A., Fahrner, R., and Wittmann, V. (2019) Triple orthogonal labeling of glycans by applying photoclick chemistry. ChemBioChem 20, 166-171 short | full
• Schmidtke, G., Schregle, R., Alvarez, G., Huber, E.M., and Groettrup, M. (2019) The 20S immunoproteasome and constitutive proteasome bind with the same affinity to PA28αβ and equally degrade FAT10. Mol. Immunol. 113, 22-30 short | full
• Schneider, T., Berg, A., Ulusoy, Z., Gamerdinger, M., Peter, C., and Kovermann, M. (2019) Conformational and functional characterization of artificially conjugated non-canonical ubiquitin dimers. Sci. Rep. 9, 19991, doi: 10.1038/s41598-019-56458-z short | full
• Shen, K., Gamerdinger, M., Chan, R., Gense, K., Martin, E.M., Sachs, N., Knight, P.D., Schlömer, R., Calabrese, A.N., Stewart, K.L., Leiendecker, L., Baghel, A., Radford, S.E., Frydman, J., and Deuerling, E. (2019) Dual role of ribosome-binding domain of NAC as a potent suppressor of protein aggregation and aging-related proteinopathies. Mol. Cell 74, 1-13 short | full
• Stevens, M., Franke, B., Skorupka, K.A., Cafiso, D.S., Pornillos, O., Mayans, O., and Norman, D.G. (2019) Exploration of the TRIM fold of MuRF1 using EPR reveals a canonical antiparallel structure and extended COS-box. J. Mol. Biol. 431, 2900-2909 short | full
• Stifel, J., Spöring, M., and Hartig, J.S. (2019) Expanding the toolbox of synthetic riboswitches with guanine-dependent aptazymes. Synth. Biol. 4, ysy022 full
• Szamosvári, D., Schuhmacher, T., Hauck, C.R., and Böttcher, T. (2019) A thiochromenone antibiotic derived from the Pseudomonas quinolone signal selectively targets the Gram-negative pathogen Moraxella catarrhalis. Chem. Sci. 10, 6624-6628 full
• Widder, P., Berner, F., Summerer, D., and Drescher, M. (2019) Double nitroxide labeling by Copper-catalyzed azide-alkyne cycloadditions with noncanonical amino acids for EPR spectroscopy. ACS Chem. Biol., 14, 839-844 short | full
• Wurmthaler, L.A., Sack, M., Gense, K., Hartig, J., and Gamerdinger, M. (2019) A tetracycline-dependent ribozyme switch allows conditional induction of gene expression in Caenorhabditis elegans. Nat. Commun. 10, 491 short | full
• Zhao, X., Scheffner, M., and Marx, A. (2019) Assembly of branched ubiquitin oligomers by click chemistry. Chem Commun 55, 13093-13095 short | full
• Zhao, X., Mißun, M., Schneider, T., Müller, F., Lutz, J., Scheffner, M., Marx, A., and Kovermann, M. (2019) Artificially linked ubiquitin dimers characterised structurally and dynamically by NMR spectroscopy. ChemBioChem 20, 1772-1777 short | full

2018

• Aichem, A., Anders, S., Catone, N., Rößler, P., Stotz, S., Berg, A., Schwab, R., Scheuermann, S., Bialas, J., Schütz-Stoffregen, M.C., Schmidtke, G., Peter, C., Groettrup, M., and Wiesner, S. (2018) The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation. Nat. Commun. 9, 3321 short | full
• Basler, M., Lindstrom, M.M., LaStant, J.J., Bradshaw, J.M., Owens, T.D., Schmidt, C., Maurits, D., Tsu, C., Overkleeft, H.S., Kirk, C.J., Langrish, C.L., and Groettrup, M. (2018) Co‐inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. EMBO Rep. 19, e46512 short | full
• Berg, A., Kukharenko, O., Scheffner, M., and Peter, C. (2018) Towards a molecular basis of ubiquitin signaling: A dual-scale simulation study of ubiquitin dimers. PLOS Comput. Biol. 14, e1006589 short | full
• Doll, F., Hassenrück, J., Wittmann, V., and Zumbusch, A. (2018) Intracellular imaging of protein–specific glycosylation. Methods Enzymol. 598, 283-319 short | full
• Fischbach, A., Krüger, A., Hampp, S., Assmann, G., Rank, L., Hufnagel, M., Stöckl, M.T., Fischer, J.M.F., Veith, S., Rossatti, P., Ganz, M., Ferrando-May, E., Hartwig, A., Hauser, K., Wiesmüller, L., Bürkle, A., and Mangerich, A. (2018) The C-terminal domain of p53 orchestrates the interplay between non-covalent and covalent poly(ADP-ribosyl)ation of p53 by PARP1. Nucleic Acids Res. 46, 804-822 short | full
• Fischer, J.M.F., Zubel, T., Jander, K., Fix, J., Trussina, I., Gebhard, D., Bergemann, J., Bürkle, A., and Mangerich, A. (2018) PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity. Arch. Toxicol. 92, 1323-1340 short | full
• Hammler, D., Marx, A., and Zumbusch, A.(2018) Fluorescence lifetime sensitive probes for monitoring ATP cleavage. Chem. Eur. J. 24, 15329-15335 short
• Heim, A., Tischer, T., and Mayer, T.U. (2018) Calcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20. EMBO Rep. 19, e46433 short | full
• Kreft, S., and Deuerling, E. (2018) Vms1: A cytosolic CAT-tailing antagonist to protect mitochondria. Trends Cell Biol.  28, 3-5 short | full
• Krüger, A., Bürkle, A., Mangerich, A., and Hauser, K. (2018) A combined approach of surface passivation and specific immobilization to study biomolecules by ATR-FTIR spectrosocpy. Biomed. Spectrosc. Imaging 7, 25-33 short | full
• Martin, E.M., Jackson, M.P., Gamerdinger, M., Gense, K., Karamanos, T.K., Humes, J.R., Deuerling, E., Ashcroft, A.E., and Radford, S.E. (2018) Conformational flexibility within the nascent polypeptide-associated complex enables its interactions with structurally diverse client proteins. J. Biol. Chem. 293, 8554-8568 short | full
• Prothiwa, M., Englmaier, F., and Böttcher, T. (2018) Competitive live-cell profiling strategy for discovering inhibitors of the Quinolone biosynthesis of Pseudomonas aeruginosa. J. Am. Chem. Soc. 140, 14019-14023 short | full
• Rütschlin, S., Gunesch, S., and Böttcher, T. (2018) One enzyme to build them all – ring-size engineered siderophores inhibit swarming motility of Vibrio. ACS Chem. Biol. 13, 1153-1158 short | full
• Sailer, C., Offensperger, F., Julier, A., Kammer, K., Walker-Gray, R., Gold, M.G., Scheffner, M., and Stengel, F. (2018) Structural dynamics of the E6AP/UBE3A-E6-p53 enzyme-substrate complex. Nat. Commun. 25, 4441 short | full
• Scheerer, D., Chi, H., McElheny, D., Samer, A., Keiderling, T.A., and Hauser, K. (2018) The role of aromatic cross-links in structure and dynamics of model three-stranded ß-sheet peptides. J. Phys. Chem. A 122, 543-553  short | full
• Scheerer, D., Chi, H., McElheny, D., Keiderling, T.A., and Hauser, K. (2018) Isotopically site-selected dynamics of a three-stranded ß-sheet peptide detected with temperature-Jump IR-spectroscopy. J. Phys. Chem. B 122, 10445-10454 full
• Scheibe, C., and Hauser, K. (2018) Orientation of lipids in solid supported lipid bilayers studied by polarized ATR-FTIR spectroscopy. Biomed. Spectrosc. Imaging 7, 17-24 short
• Schmidt, C., Berger, T., Groettrup, M., and Basler, M. (2018) Immunoproteasome inhibition impairs T and B cell activation by restraining ERK signaling and proteostasis. Front. Immunol. 9, 2386 short | full
• Schregle, R., Mah, M.M., Mueller, S., Aichem, A., Basler, M., and Groettrup, M. (2018) The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions. Immunogenetics 70, 429-438 short | full
• Szamosvári, D., Rütschlin, S., and Böttcher, T. (2018) From pirates and killers: does metabolite diversity drive bacterial competition? Org. Biomol. Chem. 16, 2814-2819 short | full
• Terron, A., Bal-Price, A., Paini, A., Monnet-Tschudi, F., Hougaard Bennekou, S., EFSA WG EPI1 Members, Leist, M., and Schildknecht, S. (2018) An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition. Arch. Toxicol. 92, 41-82 short | full
• Teusel, F., Henschke, L., and Mayer, T.U. (2018) Small molecule tools in mitosis research. Methods Cell Biol. 144, 137-155 short | full
• Wurmthaler, L.A., Klauser, B., and Hartig, J.S. (2018) Highly motif- and organism-dependent effects of naturally occurring hammerhead ribozyme sequences on gene expression. RNA Biol. epub ahead of print, 15, 231-234 short | full
• Yushchenko, T., Deuerling, E., and Hauser, K. (2018) Insights into the aggregation mechanism of polyQ proteins with different glutamine repeat lengths. Biophys. J. 114, 1847-1857 short | full

2017

• Cattani, J., Subramaniam, V., and Drescher, M. (2017) Room-temperature in-cell EPR spectroscopy: alpha-Synuclein disease variants remain intrinsically disordered in the cell. Phys. Chem. Chem. Phys. 19, 18147-18151 short | full
  
• Chu, L., Gruber, A., Ast, M., Schmitz-Esser, S., Altensell, J., Neuhaus, H.E., Kroth, P.G., and Haferkamp, I. (2017) Shuttling of (deoxy-) purine nucleotides between compartments of the diatom Phaeodactylum tricornutum. New Phytol. 213, 193-205 short | full
• Dold, J.E.G.A., Pfotzer, J., Späte, A.-K., and Wittmann, V. (2017) Dienophile-modified mannosamine derivatives for metabolic labeling of sialic acids: A comparative study. ChemBioChem 18, 1242-1250 short | full
• Ermert, S., Hacker, S.M., Buntru, A., Scheffner, M., Hauck, C.R., and Marx, A. (2017) Different enzymatic processing of γ-phosphoramidate and γ-phosphoester-modified ATP-analogues. ChemBioChem 18, 378-381 short | full
• Ermert, S., Marx, A., and Hacker, S.M. (2017) Phosphate-modified nucleotides for monitoring enzyme activity. Top. Curr. Chem. 375, 28 short | full
• Fallah, M.A., Gerding, H.R., Scheibe, C., Drescher, M., Karreman, C., Schildknecht, S., Leist, M., and Hauser, K. (2017) Simultaneous IR-spectroscopic observation of α-synuclein, lipids, and solvent reveals an alternative membrane-induced oligomerization pathway. ChemBioChem doi:10.1002/cbic.201700355 short | full
• Felletti, M., Bieber, A., and Hartig, J.S. (2017) The 3′-untranslated region of mRNAs as a site for ribozyme cleavage-dependent processing and control in bacteria. RNA Biol 14, 1522-1533 short | full
• Heim, A., Rymarczyk, B., and Mayer, T.U. (2017) Regulation of cell division. Adv. Exp. Med. Biol. 953, 83-116 short | full 
• Locke, J., Joseph, A.P., Peña, A., Möckel, M.M., Mayer, T.U., Topf, M., and Moores, C.A. (2017) Structural basis of human kinesin-8 function and inhibition. Proc. Natl. Acad. Sci. USA 114, E9539-E9548 short | full
• Möckel, M.M., Heim, A., Tischer, T., and Mayer, T.U. (2017) Xenopus laevis Kif18A is a highly processive kinesin required for meiotic spindle integrity. Biol. Open 6, 463-470 short | full
• Popp, A., Scheerer, D., Heck, B., and Hauser, K. (2017) Biomolecular dynamics studied with IR-spectroscopy using quantum cascade lasers combined with nanosecond perturbation techniques. Spectrochim. Acta A Mol. Biol. Spectrosc. 181, 192-199 short | full
• Robotta, M., Cattani, J., Martins, J.C., Subramaniam, V., and Drescher, M. (2017) Alpha-Synuclein disease mutations are structurally defective and locally affect membrane binding. J. Am. Chem. Soc. 139, 4254-4257 short | full
• Rütschlin, S., Gunesch, S., and Böttcher, T. (2017) One enzyme, three metabolites: Shewanella algae controls siderophore production via the cellular substrate pool. Cell Chem. Biol. 24, 598-604 short | full
• Schildknecht, S., Di Monte, D.A., Pape, R., Tieu, K., and Leist, M. (2017) Tipping points and endogenous determinants of nigrostriatal degeneration by MPTP. Trends Pharmacol. Sci. 38, 541-555 short | full
• Spinnenhirn, V., Bitzer, A., Aichem, A., and Groettrup, M. (2017) Newly translated proteins are substrates for ubiquitin, ISG15, and FAT10. FEBS Lett. 591, 186-195 short | full
• Szamosvári, D., and Böttcher, T. (2017) An unsaturated quinolone N-oxide of Pseudomonas aeruginosa modulates growth and virulence of Staphylococcus aureus. Angew. Chem. Int. Ed. 56, 7271-7275 short | full
• Walker-Gray, R., Stengel, F., and Gold, M.G. (2017) Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and novel crosslinking approaches. Proc. Natl. Acad. Sci. USA 114, 10414-10419 short | full
• Zhao, X., Lutz, J., Höllmüller, E., Scheffner, M., Marx, A., and Stengel, F. (2017) Identification of proteins interacting with ubiquitin chains. Angew. Chem. Int. Ed. 56, 15764-15768 short| full

2016

• Aichem, A., and Groettrup, M. (2016) The ubiquitin-like modifier FAT10 in cancer development. Int. J. Biochem. Cell Biol. 79, 451-461 short | full
• Al-Obaidi, N., Kastl, J., and Mayer, T.U. (2016) Small molecule approach to study the function of mitotic kinesins. Methods Mol. Biol. 1413, 283-299 short | full
• Al-Obaidi, N., Mitchison, T.J., Crews, C.M., and Mayer, T.U. (2016) Identification of MAC1: A small molecule that rescues spindle bipolarity in monastrol-treated cells. ACS Chem. Biol. 11, 1544-1551 short | full
• Buntz, A., Wallrodt, S., Gwosch, E., Schmalz, M., Beneke, S., Ferrando-May, E., Marx, A., and Zumbusch, A. (2016) Real-time cellular imaging of protein poly(ADP-ribos)ylation. Angew. Chemie Int. Ed. 55, 11256-11260 short | full
• Chu, L., Ewe, D., Río Bártulos, C., Kroth, P.G., and Gruber, A. (2016) Rapid induction of GFP expression by the nitrate reductase promoter in the diatom Phaeodactylum tricornutum. PeerJ. 4, e2344 short | full
• Dauner, M., Batroff, E., Bachmann, V., Hauck, C.R., and Wittmann, V. (2016) Synthetic glycosphingolipids for live-cell labeling. Bioconjugate Chem. 27, 1624-1637 short | full
• Doll, F., Buntz, A., Späte, A.-K., Schart, V.F., Timper, A., Schrimpf, W., Hauck, C.R., Zumbusch, A., and Wittmann, V. (2016) Visualization of protein-specific glycosylation inside living cells. Angew. Chemie Int. Ed. 55, 2262-2266 short | full
• Faini, M., Stengel, F., and Aebersold, R. (2016) The evolving contribution of mass spectrometry to integrative structural biology. J. Am. Soc. Mass Spectrom. 27, 966-974 short | full
• Felletti, M., Stifel, J., Wurmthaler, L.A., Geiger, S., and Hartig, J.S. (2016) Twister ribozymes as highly versatile expression platforms for artificial riboswitches. Nat. Commun. 7, 12834 short | full
• Gamerdinger, M. (2016) Protein quality control at the ribosome: focus on RAC, NAC and RQC. Essays Biochem. 60, 203-212 short | full
• Hanebuth, M.A., Kityk, R., Fries, S.J., Jain, A., Kriel, A., Albanese, V., Frickey, T., Peter, C., Mayer, M. P., Frydman, J., and Deuerling, E. (2016) Multivalent contacts of the Hsp70 Ssb contribute to its architecture on ribosomes and nascent chain interaction. Nat. Commun. 7, 13695 short | full
• Henke, K., Welte, W., and Hauser, K. (2016) Direct monitoring of β-sheet formation in the outer membrane protein TtoA assisted by TtOmp85. Biochemistry 55, 4333-4343 short | full
• Kukharenko, O., Sawade, K., Steuer, J., and Peter, C. (2016) Using dimensionality reduction to systematically expand conformational sampling of intrinsically disordered peptides. J. Chem. Theory Comput. 12, 4726-4734 short | full
• Möckel, M.M., Hund, C., and Mayer, T.U. (2016) Chemical genetics approach to engineer kinesins with sensitivity towards a small-molecule inhibitor of Eg5. ChemBioChem 17, 2042-2045 short | full
• Mosadeghi, R., Reichermeier, K.M., Winkler, M., Schreiber, A., Reitsma, J.M., Zhang, Y., Stengel, F., Cao, J., Kim, M., Sweredoski, M.J., Hess, S., Leitner, A., Aebersold, R., Peter, M., Deshaies, R.J., and Enchev, R.I. (2016) Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle. Elife doi: 10.7554/eLife.12102.  short | full
• Mulder, M.P., Witting, K., Berlin, I., Pruneda, J.N., Wu, K.P., Chang, J.G., Merkx, R., Bialas, J., Groettrup, M., Vertegaal, A.C., Schulman, B.A., Komander, D., Neefjes, J., El Oualid, F., and Ovaa, H. (2016) A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes. Nat. Chem. Biol. 12, 523-530 short | full
• Nikolay, R., Schmidt, S., Schlömer, R., Deuerling, E., and Nierhaus, K. (2016) Ribosome assembly as antimicrobial target. Antibiotics 5, 2 short | full
• Popp, A., Scheerer, D., Heng, C., Keiderling, T.A., and Hauser, K. (2016) Site-specific dynamics of β-sheet peptides with ^DPro-Gly turns probed by laser-excited temperature-jump infrared spectroscopy. ChemPhysChem 17, 1273-1280 short | full
• Prothiwa, M., Szamosvári, D., Glasmacher, S., and Böttcher, T. (2016) Chemical probes for competitive profiling of the quorum sensing signal synthase PqsD of Pseudomonas aeruginosa. Beilstein J. Org. Chem. 12, 2784-2792 short | full
• Rank, L., Veith, S., Gwosch, E. C., Demgenski, J., Ganz, M., Jongmans, M.C., Vogel, C., Fischbach, A., Buerger, S., Fischer, J.M.F., Zubel, T., Stier, A., Renner, C., Schmalz, M., Beneke, S., Groettrup, M., Kuiper, R.P., Bürkle, A., Ferrando-May, E., and Mangerich, A. (2016) Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells. Nucleic Acids Res. 44, 10386-10405 short | full
• Rosazza, C., Deschout, H., Buntz, A., Braeckmans, K., Rols, M.P., and Zumbusch, A. (2016) Endocytosis and endosomal trafficking of DNA after gene electrotransfer in vitro. Mol. Ther. Nucleic Acids 5, e286 short | full
• Roser, P., Schmidt, M.J., Drescher, M., and Summerer, D. (2016) Site-directed spin labeling of proteins for distance measurements in vitro and in cells. Org. Biomol. Chem. 14, 5468-5476 short | full
  
• Schneider, D., Schneider, T., Aschenbrenner, J., Mortensen, F., Scheffner, M., and Marx, A. (2016) Anionic surfactants enhance click reaction-mediated protein conjugation with ubiquitin. Bioorg. Med. Chem. 24, 995-1001 short | full
• Späte, A.-K., Dold, J.E.G.A., Batroff, E., Schart, V.F., Wieland, D.E., Baudendistel, O.R., and Wittmann, V. (2016) Exploring the potential of Norbornene-modified Mannosamine derivatives for metabolic glycoengineering. ChemBioChem 17, 1374-1383 short | full
• Szamosvári, D., Reichle, V.F., Jureschi, M., and Böttcher, T. (2016) Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa. Chem. Commun. 52, 13440-13443 short | full
• Wallrodt, S., Buntz, A., Wang, Y., Zumbusch, A, and Marx, A. (2016) Bioorthogonally functionalized NAD⁺ analogues for in-cell visualization of poly(ADP-ribose) formation. Angew. Chem. Int. Ed. 55, 7660-7664 short | full

2015

• Aufderheide, A., Beck, F., Stengel, F., Hartwig, M., Schweitzer, A., Pfeifer, G., Goldberg, A.L., Sakata, E., Baumeister, W., and Förster, F. (2015) Structural characterization of the interaction of Ubp6 with the 26S proteasome. Proc. Natl. Acad. Sci. USA 112, 8626-8631 short | full
• Bialas, J., Groettrup, M., and Basler, M. (2015) Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation. PLoS One 10, e0120329 short | full
• Braun, J., Möckel, M.M., Strittmatter, T., Marx, A., Groth, U., and Mayer, T.U. (2015) Synthesis and biological evaluation of optimized inhibitors of the mitotic kinesin Kif18A. ACS Chem. Biol. 10, 554-560 short | full
• Deutzmann, A., Ganz, M., Schönenberger, F., Vervoorts, J., Kappes, F., and Ferrando-May, E. (2015) The human oncoprotein and chromatin architectural factor DEK counteracts DNA replication stress. Oncogene 34, 4270-4277 short | full
• Donten, M.L., Hassan, S., Popp, A., Halter, J., Hauser, K., and Hamm, P. (2015) pH-Jump induced leucine zipper folding beyond the diffusion limit. J. Phys. Chem. B 119, 1425-1432 short | full
• Estrada Mallarino, L., Fan, E., Odermatt, M., Müller, M., Lin, M., Liang, J., Heinzelmann, M., Fritsche, F., Apell, H.-J., and Welte, W. (2015) TtOmp85, a β-barrel assembly protein, functions by barrel augmentation. Biochemistry 54, 844-852 short | full
• Gamerdinger, M., Hanebuth, M.A., Frickey, T., and Deuerling, E. (2015) The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum. Science 348, 201-207 short | full
• Hacker, S.M., Welter, M., and Marx, A. (2015) Synthesis of γ-phosphate-labeled and doubly labeled adenosine triphosphate analogs. Curr. Protoc. Nucleic Acid Chem. 60, 13.14.1-13.14.25 short | full
• Hacker, S.M., Buntz, A., Zumbusch, A., and Marx, A. (2015) Direct monitoring of nucleotide turnover in human cell extracts and cells by fluorogenic ATP analogs. ACS Chem. Biol. 10, 2544-2552 short | full
• Heim, A., Konietzny, A., and Mayer, T.U. (2015) Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit. EMBO Rep. 16, 1501-1510 short | full
• Honegger, A., Schilling, D., Bastian, S., Sponagel, J., Sültmann, H., Scheffner, M., Hoppe-Seyler, K., and Hoppe-Seyler, F. (2015) Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells. PLoS Pathog. 11, e1004712 short | full
• Kastl, J., Braun, J., Prestel, A., Möller, H.M., Huhn, T., and Mayer, T.U. (2015) Mad2 Inhibitor-1 (M2I-1): A small molecule protein−protein interaction inhibitor targeting the mitotic spindle assembly checkpoint. ACS Chem. Biol. 10, 1661-1666 short | full
• Klauser, B., Atanasov, J., Siewert, L.K., and Hartig, J.S. (2015) Ribozyme-based aminoglycoside switches of gene expression engineered by genetic selection in S. cerevisiae. ACS Synth. Biol. 4, 516-525 short | full
• Mortensen, F., Schneider, D., Barbic, T., Sladewska-Marquardt, A., Kühnle, S., Marx, A., and Scheffner, M. (2015) Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated protein ubiquitination. Proc. Natl. Acad. Sci. USA 112, 9872-9877 short | full
• Nikolay, R., Schlömer, R., Müller, S., and Deuerling, E. (2015) Fluorescence-based monitoring of ribosome assembly landscapes. BMC Mol. Biol. 16, 3 full
• Ott, A.-K., Locher, L., Koch, M. and Deuerling, E. (2015) Functional dissection of the nascent polypeptide-associated complex in Saccharomyces cerevisiae. PLoS One, e0143457 short | full
• Preissler, S., Reuther, J., Koch, M., Scior, A., Bruderek, M., Frickey, T., and Deuerling, E. (2015) Not4-dependent translation repression is important for cellular protein homeostasis in yeast. EMBO J. 34, 1905-1924 short | full
• Rösner, D., Schneider, T., Schneider, D., Scheffner, M., and Marx, A. (2015) Click chemistry for targeted protein ubiquitylation and ubiquitin chain formation. Nat. Protoc. 10, 1594-1611 short | full
• Schönenberger, F., Deutzmann, A., Ferrando-May, E., and Merhof, D. (2015) Discrimination of cell cycle phases in PCNA-immunolabeled cells. BMC Bioinformatics 16, 180 short | full

2014

• Aichem, A., Catone, N., and Groettrup, M. (2014) Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1. FEBS J. 281, 1848-1859 short | full
• Bußkamp, H., Batroff, E., Niederwieser, A., Abdel-Rahman, O.S., Winter, R.F., Wittmann, V., and Marx, A. (2014) Efficient labelling of enzymatically synthesized vinyl-modified DNA by an inverse-electron- demand Diels–Alder reaction. Chem. Commun. 50, 10827 short | full
• Fischer, J. M. F., Popp, O., Gebhard, D., Veith, S., Fischbach, A., Beneke, S., Leitenstorfer, A., Bergemann, J., Scheffner, M., Ferrando-May, E., Aswin Mangerich, A., and Bürkle, A. (2014) Poly(ADP-ribose)-mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function. FEBS J. 281, 3625-3641 short | full
• Gamerdinger, M., and Deuerling, E. (2014) Trigger Factor flexibility. Science 344, 590-591 full
• Gutiérrez Acosta, O. B., Hardt, N., Hacker, S.M., Strittmatter, T., Schink, B., and Marx, A. (2014) Thiamine pyrophosphate stimulates acetone activation by Desulfococcus biacutus as monitored by a fluorogenic ATP analogue. ACS Chem. Biol. 9, 1263-1266 short | full
• Hacker, S. M., Hintze, C., Marx, A., and Drescher, M. (2014) Monitoring enzymatic ATP hydrolysis by EPR spectroscopy. Chem. Commun. 50, 7262-7264 short | full
• Hacker, S. M., Mortensen, F., Scheffner, M., and Marx, A. (2014) Selective monitoring of the enzymatic activity of the tumor suppressor Fhit. Angew. Chem. Int. Ed. 53, 10247-10250 short | full
• Häfner, J., Mayr, M.I., Möckel, M.M., and Mayer, T.U. (2014) Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A. Nat. Commun. 5, 4397 short | full
• Heck, B. S., Doll, F., and Hauser, K. (2014) Length-dependent conformational transitions of polyglutamine repeats as molecular origin of fibril initiation. Biophys. Chem. 185, 47-57 short | full
• Henke, K., Odermatt, M., Welte, W., and Hauser K. (2014) Stability of the Thermus thermophilus outer membrane protein TtoA against heat and denaturants. Biomed. Spectrosc. Imaging 3, 51-56 full
• Nikolay, R., Schlömer, R., Schmidt, S., Müller, S., Heubach, A., and Deuerling, E. (2014) Validation of a fluorescence-based screening concept to identify ribosome assembly defects in Escherichia coli. Nucleic Acids Res. 42, e100 short | full
• Popp, A., Wu, L., Keiderling, T.A., and Hauser, K. (2014) Effect of hydrophobic interactions on the folding mechanism of β-hairpins. J. Phys. Chem. 118, 14234-14242 short | full
• Robotta, M., Gerding, H. R., Voge,l A., Hauser, K., Schildknecht, S., Karreman, C., Leist, M., Subramaniam, V., and Drescher, M. (2014) Alpha-Synuclein binds to the inner membrane of mitochondria in an α-helical conformation. Chembiochem 15, 2499-2502 short | full
• Scheffner, M., and Kumar, S. (2014) Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects. BBA Mol. Cell Res. 1843, 61-74 short | full
• Schildknecht, S., Weber, A., Gerding, H. R., Pape, R., Robotta, M., Drescher, M., Marquardt, A., Daiber, A., Ferger, B., and Leist, M. (2013) The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite. Curr. Med. Chem. 21, 365-376 short | full
• Schmidtke, G., Aichem, A., and Groettrup, M. (2014) FAT10ylation as a signal for proteasomal degradation. BBA Mol. Cell Res. 1843, 97-102 short | full
• Schneider, T., Schneider, D., Rösner, D., Malhotra, S., Mortensen, F., Mayer, T. U., Scheffner, M., and Marx, A. (2014) Dissecting ubiquitin signaling with linkage-defined and protease resistant ubiquitin chains. Angew. Chem. Int. Ed. 53,12925-12929 short | full
• Späte, A.-K., Bußkamp, H., Niederwieser, A., Schart, V. F.,  Marx, A., and Wittmann, V. (2014) Rapid labeling of metabolically engineered cell-surface glycoconjugates with a carbamate-linked cyclopropene reporter. Bioconjugate Chem. 25, 147–154 short | full
• Späte, A.-K., Schart, V. F., Häfner, J., Niederwieser, A., Mayer, T. U. and Wittmann, V. (2014) Expanding the scope of cyclopropene reporters for the detection of metabolically engineered glycoproteins by Diels-Alder reactions. Beilstein J. Org. Chem. 10, 2235-2242 short | full
• Späte, A.-K., Schart, V. F., Schöllkopf, S., Niederwieser, A., and Wittmann, V. (2014) Terminal alkenes as versatile chemical reporter groups for metabolic oligosaccharide engineering. Chem. Eur. J. 20, 16502-16508 short | full

2013

• Azarkh, M., Singh, V., Okle, O., Seemann, I.T., Dietrich, D.R., Hartig, J.S., and Drescher, M. (2013) Site-directed spin-labeling of nucleotides and the use of in-cell EPR to determine long-range distances in a biologically relevant environment. Nat. Protoc. 8, 131-147 short | full
• Bürkle, A., and Virág, L. (2013) Poly(ADP-ribose): PARadigms and PARadoxes. Mol. Aspects Med. 34, 1046-1065 short | full
• Hacker, S.M., Hardt, N., Buntru, A., Pagliarini, D., Möckel, M., Mayer, T.U., Scheffner, M., Hauck, C.R., and Marx, A. (2013) Fingerprinting differential active site constraints of ATPases. Chem. Sci. 4, 1588-1596 short | full
• Hacker, S.M., Pagliarini, D., Tischer, T., Hardt, N., Schneider, D., Mex, M., Mayer, T.U., Scheffner, M., and Marx, A. (2013) Fluorogenic ATP analogues for online monitoring of ATP consumption: Observing ubiquitin activation in real-time. Angew. Chem. Int. Ed. 52, 11916-11919 short | full
• Hardt, N., Hacker, S.M., and Marx, A. (2013) Synthesis and Fluorescence Characteristics of ATP-based FRET probes. Org. Biomol. Chem. 11, 8298-82305 short | full
• Hörmanseder, E., Tischer, T., and Mayer. T.U. (2013) Modulation of cell cycle control during oocyte-to-embryo transitions. EMBO J. 14, 2191-2203 short | full
• Kirstein-Miles, J., Scior, A., Deuerling, E., and Morimoto R.I. (2013) The nascent polypeptide associated complex is a key regulator of proteostasis. EMBO J. 15, 1451-1468 short | full
• Kühnle, S., Mothes, B., Matentzoglu, K., and Scheffner M. (2013) Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc. Proc. Natl. Acad. Sci. USA 110, 8888-8893  short | full
• Martello, R., Mangerich, A., Sass, S., Dedon, P.C., and Bürkle, A. (2013) Quantification of cellular Poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics. ACS Chem. Biol. 8, 1567-1575 short | full
• Niederwieser, A., Späte, A.-K., Nguyen, L.D.,  Jüngst, C.,  Reutter, W., and  Wittmann, V. (2013) Two-color glycan labeling of live cells by a combination of Diels–Alder and click chemistry. Angew. Chem. Int. Ed. 52, 4265-4268 short | full
• Rosazza, C., Buntz, A., Rieß, T., Wöll, D., Zumbusch, A., and Rols, M.-P. (2013) Intracellular tracking of single-plasmid DNA particles after delivery by electroporation. Mol. Ther. 21, 2217–2226 short | full
• Saragliadis, A., and Hartig, J.S. (2013) Ribozyme-based transfer RNA switches for post-transcriptional control of amino acid identity in protein synthesis. J. Am. Chem. Soc. 135, 8222-8226 short | full
• Schildknecht, S., Gerding, H. R., Karreman, C., Drescher, M., Lashuel, H. A., Outeiro, T. F., DiMonte, D. A., and Leist, M. (2013) Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. J. Neurochem. 125, 491-511 short | full
• Schildknecht, S., Karreman, C., Pöltl, D., Efremova, L., Kullmann, C., Gutbier, S., Gut, A., Scholz, D., Gerding, H. R., and Leist, M. (2013) Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases. ALTEX 30, 427-444 short | full
• Schneider, D., Schneider, T., Rösner, D., Scheffner, M., and Marx A. (2013) Improving bioorthogonal protein ubiquitylation by click reaction. Bioorg. Med. Chem. 21, 3430-3435 short | full

2012

• Aichem, A., Kalveram, B., Spinnenhirn, V., Kluge, K., Catone, N., Johansen, T., and Groettrup, M. (2012) The proteomic analysis of FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. J. Cell Sci. 125, 4576-4585 short | full
• Drescher, M., Huber, M., and Subramaniam, V. (2012) Hunting the Chameleon: Structural conformations of the intrinsically disordered protein alpha-Synuclein. ChemBioChem 13, 761-768 short | full
• Eger, S., Scheffner, M., Marx, A., Rubini, M. (2012) Formation of ubiquitin dimers via azide–alkyne click reaction. Methods Mol. Biol. 832, 589-596 short | full
• Florian, S., and Mayer, T.U. (2012) The functional antagonism between Eg5 and dynein in spindle bipolarization is not compatible with a simple push-pull model. Cell Rep. 1, 408-416 short | full
• Gamerdinger, M., and Deuerling, E. (2012) Macrolides: the plug is out. Cell 151, 469. short | full
• Hacker, S.M., Mex, M., and Marx, A. (2012) Synthesis and stability of phosphate modified ATP analogues. J. Org. Chem. 77, 10450-10454 short | full
• Mangerich, A., and Bürkle, A. (2013) Pleiotropic cellular functions of PARP1 in longevity and aging: Genome maintenance meets inflammation. Oxid. Med. Cell Longev. 2012, 321653  short | full
• Preissler, S., and Deuerling, E. (2012) Ribosome-associated chaperones as key players in proteostasis. Trends Biochem. Sci. 37, 274-283 short | full
• Rani, N., Aichem, A., Schmidtke, G., Kreft, S., and Groettrup, M. (2012) FAT10 and NUB1L bind the VWA domain of Rpn10 and Rpn1 to enable proteasome-mediated proteolysis. Nat. Commun. 3, 749 short | full
• Richet, E., Pooler, A.M., Rodriguez, T., Novoselov, S.S., Schmidtke, G., Groettrup, M., Hanger, D.P. Cheetham, M.E., and van der Spuy, J. (2012) NUB1 modulation of GSK3beta reduces tau aggregation. Hum. Mol. Genet.  21, 5254-5267 short | full
• Robotta, M., Hintze, C., Schildknecht, S., Zijlstra, N., Jüngst, C., Karreman, C, Huber, M., Leist, M., Subramaniam, V., and Drescher, M. (2012) Locally resolved membrane binding affinity of the N-terminus of α-Synuclein. Biochemistry 51, 3960–3962 short | full
• Schildknecht, S., Karreman, C., Daiber, A., Zhao, C., Hamacher, J., Perlman, D., Jung, B., van der Loo, B., O´Connor, P., Leist, M., Ullrich, V., and Bachschmid, M.M. (2012) Autocatalytic nitration of prostaglandin endoperoxide synthase-2 by nitrite inhibits prostanoid formation in rat alveolar macrophages. Antiox. & Redox Signal. 17, 1393-1406 short | full
• Schildknecht, S., Kirner, S., Henn, A., Gasparic, K., Pape, R., Efremova, L., Maier, O., Fischer, R., and Leist, M. (2012) Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions. ALTEX 29, 261-274 short | full
• Tischer, T., Hörmanseder, E., and Mayer, T.U. (2012) The APC/C inhibitor XErp1/Emi2 is essential for Xenopus early embryonic divisions. Science 338, 520-524 short | full