A core issue of the CRC 969 are university-wide seminars dedicated to the presentation and discussion of high-profile research data from expert scientists in the field of proteostasis.
Besides the regular seminars of this summer term, there will be an additional CRC 969 seminar given by Prof. Judith Frydman from Stanford University on July 19th, in Room M629, at 11:45 h.
Judith will talk about “Molecular Origami: Protein Folding and Misfolding in Health and Disease“.
Summer term 2023
Time: Tuesdays, 15:15 h
Location: Room M629
| 18 April 2023
|
Fundamental Principles in Protein Chemistry: Insights from Evolutionary “Time-Travel” to the Past and to the Future
Prof. Magnus Wolf-Watz, Umeå University |
| 09 May 2023
|
Here Be Clippases! Searching for Unusual Deubiquitinases in Uncharted Territory
Prof. Kay Hofmann, University of Cologne |
| 23 May 2023
|
Development of a Tool Box of Chemical Probes for Selective Protein Degradation
Prof. Stefan Knapp, University of Frankfurt |
| 13 June 2023
|
Mass Spectrometry-Based Techniques to Elucidate the Sugar Code
Prof. Kevin Pagel, FU Berlin |
| 11 July 2023
|
How to Make Drugs (Fast) Prof. Helge Bode, MPI Marburg |
| 18 July 2023
|
Next-Level Riboswitch Development – Implementation of Capture-SELEX allows Fast and Easy Identification of New Synthetic Riboswitches
Prof. Beatrix Süß, TU Darmstadt |
Winter term 2022/2023
Time: Tuesdays, 15:15 h
Location: Room A704
| 08 November 2022
|
Quantifying Heterogeneous Protein Interactions – What We Learn About Structure, Function and Evolution
Prof. Justin Benesch, University of Oxford |
| 22 November 2022
|
Nitrogen-Vacancy Centers in Diamond: Nanoscale Sensors for Physics and Biology
Prof. Christian Degen, ETH Zurich |
| 06 December 2022
|
A Biochemical Approach to the Understanding of Post-Translational Modifications during Bacterial Infections
Prof. Aymelt Itzen, UKE Hamburg |
| 17 January 2023
|
Optimizing Synthetic Pathways – Between Evolution and Design Prof. Sven Panke, ETH Zurich at Basel |
| 31 January 2023
|
Designer Proteins for Decoding the Function of Epigenetic DNA Modifications
Prof. Daniel Summerer, University of Dortmund |
Summer term 2022
Time: Tuesdays, 15:15 h
Location: Room A704
|
19 April 2022 |
Neural Network Methods in DEER and RIDME Spectroscopy of Spin-Labelled Proteins
Prof. Ilya Kuprov, University of Southampton |
| 17 May 2022 | The Conformational Equilibrium of the Neuropeptide Y2 G-Protein Coupled Receptor in Membranes
Prof. Daniel Huster, University of Leipzig |
| 31 May 2022 | Interrogating Transmembrane Signaling by Advanced Light Microscopy
Prof. Jacob Piehler, University of Osnabrück |
| 28 June 2022 | Targeted Protein Degradation to Disrupt Gene Control in Cancer
Dr. Georg Winter, CeMM, Vienna |
| 05 July 2022 | Assembly and Aggregation – How to Unravel Control Mechanisms with Mass Spectrometry
Prof. Nina Morgner, University of Frankfurt |
| 12 July 2022 | Development of a Tool Box of Chemical Probes for Selective Protein Degradation
Prof. Stefan Knapp, University of Frankfurt |
Winter term 2021/2022: We resume our seminar talks on campus!
Time: Tuesdays, 15:15 h
Location: Room A704
Note that all participants have to stick to the 2G-rule of the University: it is vital that you are either vaccinated or recovered! Please keep the maximal possible distance in the lecture hall and wear a medical face mask. If you have typical corona symptoms such as high temperature and/or cough you are not allowed to enter the University!
| 30 November 2021
|
Impact of Division History on Neural Stem Cells
Dr. Annina Denoth-Lippuner, University of Zurich |
| 18 January 2022
|
POSTPONED! Mechanisms of Folding and Assembly of Newly Synthesized Proteins
Prof. Bernd Bukau, University of Heidelberg |
| 01 February 2022
|
POSTPONED! Chlamydia – Host Cell Interactions at the Crossroad of Metabolism and Immune Defence Prof. Thomas Rudel, University of Würzburg |
| 08 February 2022
|
POSTPONED! The Modular Proteome and Its Biological Significance
Prof. Ruedi Aebersold, ETH Zurich |
Summer term 2021: Due to the Corona pandemic, all seminars of this term will be given online via Zoom Sessions
Please see also the Data Protection Information
Time: Tuesdays, 15:15 h
| 01 June 2021
|
Parkin is the First E3 Ligase for the Ubiquitin-Like Modifier FAT10, which Inhibits Parkin Activation and Mitophagy
Dr. Nicola Roverato, University of Konstanz |
| 15 June 2021
|
Deubiquitylases: Druggable Regulators of Protein and Organelle Homeostasis
Prof. Sylvie Urbé, University of Liverpool |
| 13 July 2020
|
Activity-Based Probes as Chemical Tools for Targeting Proteases
Prof. Thomas Böttcher, University of Vienna |
| 20 July 2021
|
Exploring the WW Domain as a Model System for the Design of Miniaturized Proteins
Prof. Franziska Thomas, University of Heidelberg |
Winter term 2020/2021: Due to the Corona pandemic, there will be no seminars in this term!
Summer term 2020: Due to the Corona pandemic, all seminars of this term will be postponed!
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 21 April 2020
|
POSTPONED! The Modular Proteome and Its Biological Significance POSTPONED!
Prof. Ruedi Aebersold, ETH Zürich |
| 23 June 2020
|
POSTPONED! Deubiquitylases: Druggable Regulators of Protein and Organelle Homeostasis POSTPONED!
Prof. Sylvie Urbé, University of Liverpool |
| 30 June 2020
|
POSTPONED! Proteolytic Control of Mitochondrial Plasticity POSTPONED!
Prof. Thomas Langer, University of Köln |
| 14 July 2020
|
POSTPONED! Discovery of Novel sGC Stimulators Riociguat and Vericiguat POSTPONED!
Prof. Joachim Mittendorf, Bayer AG |
Winter term 2019/2020
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 22 October 2019
|
Chemical Physiology of Antibody Conjugates and Natural Products
Dr. Gonçalo Bernardes, University of Cambridge |
| 26 November 2019
|
Macromolecular Phase Separation in Germ Cell Fate
Dr. Shambaditya Saha, IMBA Wien |
| 03 December 2019
|
Cycling to Death: Separase-Triggered Apoptosis by Cleavage of Bcl2 Proteins Enforces Minimal Length of Mitosis
Prof. Olaf Stemmann, University of Bayreuth |
| 10 December 2019
|
Visualization of Ribosomal Subunit Precursors using Cryo-Electron Microscopy – Mechanistic and Evolutionary Insights
Dr. Rainer Nikolay, Charité Berlin |
Summer term 2019
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 07 May 2019
|
Protein Dynamics from Integrative NMR Research
Prof. Dr. Magnus Wolf-Watz, Umeå University |
| 21 May 2019
|
A Beta Barrel for Oil Transport Through Lipid Membranes: Dynamic NMR Structures of AlkL
Dr. Loren Andreas, MPI Göttingen |
| 04 June 2019
|
Ultrahigh-Throughput Evolution and Characterization of RNA Using Droplet-Based Microfluidics
Dr. Michael Ryckelynck, University of Strasbourg |
| 09 July 2019
|
Expanding The Genetic Code – Protein Chemistry in Living Systems
Prof. Dr. Kathrin Lang, TU Munich |
Winter term 2018/2019
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 06 November 2018
|
Different Mitochondrial Unfolded Protein Response Axes to Safeguard Mitochondria
Prof. Dr. Christian Münch, University of Frankfurt |
| 27 November 2018
|
How Bacterial Lipoproteins Influence our Immune System
Prof. Dr. Fritz Götz, University of Tübingen |
| POSTPONED!! 04 December 2018 |
From its Evolutionary Origin to the Structure of the Metabolic Network of the Eukaryotic Cell
Prof. Dr. Markus Ralser, Charité Berlin |
| 11 December 2018
|
Killing Cells In and Out of Mitosis
Prof. Dr. Andreas Villunger, Medical University Innsbruck |
| 18 December 2018
|
Activity-Based Profiling of Ubiquitin E3 Ligases: From Parkin to the Impalpable
Dr. Satpal Virdee, University of Dundee |
Summer term 2018
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 17 April 2018
|
Cats but not Rats? Hominids but not Hamsters?
A Study into the Molecular Mechanism of Type 2 Diabetes Using 2D IR Spectroscopy Prof. Dr. Martin Zanni, University of Wisconsin, Madison |
| 08 May 2018
|
Programmable Receptors and Reagents for Chromatin Chemical Biology
Prof. Dr. Daniel Summerer, University of Dortmund |
| 29 May 2018
|
Chaperone Control of Neurotoxic Protein Aggregation
Prof. Dr. Stefan Rüdiger, University of Utrecht |
| 05 June 2018
|
In vitro Cross-Reactivity of Parkinson’s Disease Protein, Alpha-Synuclein: Consequences for Amyloid Formation
Prof. Dr. Pernilla Wittung-Stafshede, Chalmers University Gothenburg |
Winter term 2017/2018
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 28 November 2017
|
Chemical Biology Tools to Perceive and Perturb Glycans and Carbohydrate Processing Enzymes in Living Systems
Prof. Dr. David Vocadlo, Simon Fraser University |
| 12 December 2017
|
A Ring to Rule Them All: From Cell Polarity to Bacterial Virulence Control
Prof. Dr. Urs Jenal, Biozentrum Basel |
| 09 January 2018
|
Unraveling Biomolecular Recognition and Dynamics in Solution using NMR-Spectroscopy and Integrative Structural Biology
Prof. Dr. Michael Sattler, TU München |
| 16 January 2018
|
A Ribozyme With Multiple Functions – Molecular Gymnastics of a Small RNA
Prof. Dr. Sabine Müller, University of Greifswald |
Summer term 2017
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 20 June 2017
|
The Role of the Two Helicases XPD and RecQ4 in Genome Maintenance
Prof. Caroline Kisker, University of Würzburg |
| 27 June 2017
|
SUMO Rules
Dr. Andrea Pichler, MPI Freiburg |
| 04 July 2017
|
New Spectroscopic and Thermodynamic Approaches for The Characterization of Macromolecule-Ligand Interactions
Prof. Dr. Dariush Hinderberger, University of Halle-Wittenberg |
| 18 July 2017
|
Conformational Control of Bacterial Clp Protease by Acyldepsipeptide Antibiotics
Prof. Dr. Heike Brötz-Oesterhelt, University of Tübingen |
Winter term 2016/2017
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 15 November 2016
|
How Pathogenic Bacteria Subvert Host Ubiquitin Signaling
Dr. Jonathan Pruneda, MRC Cambridge |
| 06 December 2016
|
Understanding Biological Nitrogen Fixation
Prof. Dr. Oliver Einsle, University of Freiburg |
| 24 January 2017
|
The Cyanobacterial Toxin Microcystin Interferes With Major Path of Carbon in Bloom-Forming Cyanobacteria
Prof. Dr. Elke Dittmann, University of Potsdam |
| 07 February 2017
|
Cellular Factors Implicated in Amyloid Fibril Homeostasis
Prof. Dr. Michael Ehrmann, University of Duisburg-Essen |
Summer term 2016
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 19 April 2016
|
Peptide-Hypermodifying Enzymes from Microbial Dark Matter
Prof. Dr. Jörn Piel, ETH Zürich |
| 26 April 2016
|
Phage Selection of Bicyclic Peptides for Application as Therapeutics
Prof. Dr. Christian Heinis, EPFL Lausanne |
| 10 May 2016
|
The Busy Life of Nascent Chains: Mechanisms of Folding of Newly Synthesized Proteins
Prof. Dr. Bernd Bukau, ZMBH Heidelberg |
| 07 June 2016
|
Structural Studies of the 26S Proteasome ex situ and in situ
Prof. Dr. Wolfgang Baumeister, MPI Martinsried |
Winter term 2015/2016
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 17 November 2015
|
Trigger Waves in Mitosis and Apoptosis
Prof. Dr. James Ferrell, Stanford University |
| 01 December 2015
|
Phase Separation in Cytoplasm: Implications for Polarity and Neurodegeneration
Prof. Dr. Tony Hyman, MPI Dresden |
| 15 December 2015
|
Prokaryotic Ubiquitin-like Tagging and Other Paths to the Bacterial Proteasome
Prof. Dr. Eilika Weber-Ban, ETH Zürich |
| 12 January 2016
POSTPONED! |
The Busy Life of Nascent Chains: Mechanisms of Folding of Newly Synthesized Proteins
Prof. Dr. Bernd Bukau, ZMBH Heidelberg |
Summer term 2015
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 28 April 2015
|
Direct Cross Talk Between PP1 and PP2A Regulates Mitotic Progression
Prof. Dr. Iain Hagan, University of Manchester |
| 05 May 2015
|
Assembling the Pieces of Protein Puzzles
Prof. Dr. Gerhard Hummer, MPI Frankfurt |
| 23 June 2015
|
Mitotic Wnt Signaling
Prof. Dr. Christoph Niehrs, IMB Mainz |
| 30 June 2015
|
The Chemical Biology of Lipid Signaling
Dr. Carsten Schultz, EMBL Heidelberg |
Winter term 2014/2015
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 18 November 2014
|
Cytotoxic Peptide-Drug Conjugates Based on Cryptophycins
Prof. Dr. Norbert Sewald, University of Bielefeld |
| 16 December 2014
|
Masters of Reduction: Control of Chromosome Segregation in Meiosis
Dr. Wolfgang Zachariae, MPI Martinsried |
| 27 January 2015
|
Synthetic DNA and RNA Architectures: Fluorescence, Photochemistry and Imaging
Prof. Dr. Hans-Achim Wagenknecht, KIT Karlsruhe |
| 03 February 2015
|
Cellular Protein Quality Control Pathways: Mechanisms and Unexpected Findings
Prof. Dr. Dieter Wolf, University of Stuttgart |
Summer term 2014
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 13 May 2014
|
Mechanism and Regulation of Macromolecular Transport across the Nuclear Envelope
Prof. Dr. Karsten Weis, ETH Zürich |
| 03 June2014
|
Chemical Oncology – Converging Chemical Biology, Cancer Genetics and Medicinal Chemistry
Prof. Dr. Daniel Rauh, TU Dortmund |
| 17 June 2014
|
Chemical Biology of AdoMet-dependent Methyltransferases: Synthetic Cofactor Analogues for Affinity-based Protein Profiling and Substrate Labeling
Prof. Dr. Elmar Weinhold, RWTH Aachen |
| 01 July 2014
|
Expanding the Epigenetic DNA Alphabet
Prof. Dr. Thomas Carell, LMU München |
Winter term 2013/2014
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 26 November 2013
|
How Separase, Cohesin & Shugoshin Choreograph the Chromosomal-Ballet of Mitosis
Prof. Dr. Olaf Stemmann, University of Bayreuth |
| 17 December 2013
|
Cyclic-di-GMP Signaling and Bacterial Biofilm Formation
Prof. Dr. Regine Hengge, Humboldt University Berlin |
| 28 January 2014
|
Translating DRiPs for Immunosurveillance
Prof. Dr. Jonathan Yewdell, NIH, Bethesda, USA |
| 11 February 2014
|
Cellular Mechanisms of Neurodegeneration
Prof. Dr. Christian Haass, University of Munich |
Summer term 2013
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 28 May 2013
|
The Molecular Basis of the von Hippel Lindau Cancer Syndrome
Prof. Dr. Wilhelm Krek, ETH Zürich, Switzerland |
| 04 June 2013
|
2 inactive 4 destruction or the tails of p63
Prof. Dr. Volker Dötsch, University of Frankfurt |
| 02 July 2013
|
Heat Shock Proteins and Protein Aggregation Diseases
Prof. Dr. Harm Kampinga, University of Groningen, The Netherlands |
| 01 August 2013
(Thursday) |
Adapting the Chemistry and Biology of Proteostasis to Ameliorate Disease
Prof. Dr. Jeff Kelly, SCRIPPS Research Institute, USA |
Winter term 2012/2013
Time: Tuesdays, 15:15 h
Location: Room A704
Get together: Before the talks, 14:55 h
| 27 November 2012
|
Signalling and Mechanics at the Human Mitotic Centromere and Kinetochore
Prof. Dr. Jason Swedlow, University of Dundee, UK |
| 18 December 2012
|
Prolyl Isomerization in Protein Folding and Protein Function
Prof. Dr. Franz-Xaver Schmid, University of Bayreuth |
| 15 January 2013
|
From Single Molecules to Cellular Function – Protein Translocation into Chloroplasts
Prof. Dr. Enrico Schleiff, University of Frankfurt |
| 19 February 2013
|
Chemical Tools in Chromatin Research
Prof. Dr. Dirk Schwarzer, University of Tübingen |
Summer term 2012
Time: Tuesdays, 17:00 h
Location: Room A703
Get together: Before the talks, 16:40 h
|
15 May 2012
|
Regulating Nuclease Activity in human DNA Repair Pathways
Prof. Dr. Orlando Schärer, Stony Brook, NY, USA |
| 19 June 2012
|
Proteostasis of Rubisco: Folding, Assembly and Activation Mediated by Chaperones
Dr. Manajit Hayer-Hartl, MPI of Biochemistry, Martinsried |
| 26 June 2012
|
Transport and Assembly of Mitochondrial Proteins
Prof. Dr. Nikolaus Pfanner, University of Freiburg |
| 17 July 2012
|
Transmembrane Signaling and Transport: Membrane Protein Dynamics Studied by Site-Directed Spin Labeling EPR
Prof. Dr. Heinz-Jürgen Steinhoff, University of Osnabrück |